Google AI offshoot DeepMind announces a major breakthrough in solving the “protein folding problem”—determining a protein’s 3D shape from its amino-acid sequence. Considered one of biology’s grand challenges due to myriad possible configurations, DeepMind’s AI system AlphaFold has demonstrated it can predict protein structures with high accuracy, vastly outperforming other more laborious, costly techniques. “It’s a game-changer,” says Andrei Lupas, an evolutionary biologist at the Max Planck Institute in Tübingen, Germany. “This will change medicine. It will change research. It will change bioengineering. It will change everything.”